McGarrett and Five-0 must track down a Russian spy who has stolen a flash drive containing classified NSA information that puts the life of a member of their Ohana at risk. Also, McGarrett finally learns why Catherine left him, and Abby continues to conceal her actual mission from Chin and Five-0.
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Brian and Rebecca are placed under quarantine by the CDC after being exposed to an unknown substance after investigating a citywide blackout. Also, trust issues arise after Rebecca catches Brian using his secret stash of NZT.